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KMID : 1189120070040020128
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대한의학유전학회지
2007 Volume.4 No. 2 p.128 ~ p.132
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A study on association of Progesterone receptor gene Polymorphism (PROGINS) with Endometriosis
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Kim Yun-Jin
Noh Ji-Hyun
Koh Jae-Whoan
Kim Yong-Bong
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Abstract
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Purpose : Endometriosis is a Steroid dependent disease with a Particular genetic background but the location of possible genomic aberrations are still poorly clarified. This study was designed to investigate the associations between the polymorphism of the progester one receptor gene (PROGINS) and endometriosls.
Methods : 100 women with surgically diagnosed and histologically confirmed endometriosis were enrolled as a patient population and a total of 110 female control subjects undergoing health examination were enrolled as control population. DNA extraction and polymerase chain reaction (PCR) were used to genotype women for the presence of the PROGINS polymorphism in peripheral blood samples. The x2-test was used to compare genotype distributions between endometriosis and controls.
Results : T1/T2 heterozygote was found to be one patient in each group, and the rest of the subjects were all T1/T1 homozygotes. There was no difference in the genotype distribution between the endometriosis group and the control group.
Conclusion : These results suggest that the Progesterone receptor gene PROGINS is not associated withthe risk for endometriosis.
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KEYWORD
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PROGINS, Progesterone receptor, Polymorphism
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